(1) Kumar S, Das G, Shin HS and Patra JK.
Dioscorea spp. (a wild edible tuber): a study on its
ethnopharmacological potential and traditional use
by the local people of Similipal Biosphere Reserve,
India. Front. Pharmacol. (2017) 8: 52.
(2) Romano R, Giordano A, Le Grottaglie L,
Manzo N, Paduano A, Sacchi R and Santini A.
Volatile compounds in intermittent frying by gas
chromatography and nuclear magnetic resonance.
Eur. J. Lipid Sci. Tech. (2013) 115: 764-73.
(3) Miyazawa M, Shimamura H and Kameoka H.
Volatile Components of the Rhizomes of Dioscorea
japonica. Nat. Prod. Lett. (1997) 9: 245-8.
(4) Ou-yang SH, Jiang T, Zhu L and Yi T. Dioscorea
nipponica Makino: a systematic review on its
ethnobotany, phytochemical and pharmacological
profiles. Chem. Cent. J. (2018) 12: 57.
(5) Jesus M, Martins AP, Gallardo E and Silvestre S.
Diosgenin: recent highlights on pharmacology and
analytical methodology. J. Anal. Methods Chem.
(2016) 2016: 4156293.
(6) Cheng WY, Kuo YH and Huang CJ. Isolation and
identification of novel estrogenic compounds in
yam tuber (Dioscorea alata Cv. Tainung No. 2). J.
Agr. Food. Chem. (2007) 55: 7350-8.
(7) Rakotobe L, Mambu L, Deville A, Dubost L,
Jeannoda V, Rakoto D and Bodo B. Clerodane
and 19-norclerodane diterpenoids from the tubers
of Dioscorea antaly. Phytochemistry (2010) 71:
1007-13.
85
Salehi B et al. / IJPR (2019), 18 (Special Issue): 68-89
(8) Sharma M, Hotpet V, Sindhura B, Kamalanathan
A, Swamy BM and Inamdar SR. Purification,
characterization and biological significance of
mannose binding lectin from Dioscorea bulbifera
bulbils. Int. J. Biol. Macromol. (2017) 102: 1146-
55.
(9) Liu H, Tsim KW, Chou GX, Wang JM, Ji LL and
Wang ZT. Phenolic compounds from the rhizomes
of Dioscorea bulbifera. Chem. Biodivers. (2011) 8:
2110-6.
(10) Tang Y, Xue YB, Zhou L, Zhang JW, Yao GM,
Luo ZW, Du G and Zhang YH. New norclerodane
diterpenoids from the tubers of Dioscorea
bulbifera. Chem. Pharm. Bull. (2014) 62: 719-24.
(11) Zhao DS, Wu ZT, Li ZQ, Wang LL, Jiang LL, Shi
W, Li P and Li HJ. Liver-specific metabolomics
characterizes the hepatotoxicity of Dioscorea
bulbifera rhizome in rats by integration of GC-MS
and 1H-NMR. J. Ethnopharmacol. (2018) 226:
111-9.
(12) Sautour M, Mitaine-Offer AC, Miyamoto T,
Dongmo A and Lacaille-Dubois MA. Antifungal
steroid saponins from Dioscorea cayenensis.
Planta Med. (2004) 70: 90-2.
(13) Ali Z, Smillie TJ and Khan IA. Two spirostan
steroid glycoside fatty esters from Dioscorea
cayenensis. Nat. Prod. Commun. (2013) 8: 323-6.
(14) Adepoju OT, Boyejo O and Adeniji PO. Effects of
processing methods on nutrient and antinutrient
composition of yellow yam (Dioscorea cayenensis)
products. Food Chem. (2018) 238: 160-5.
(15) Lee HJ, Watanabe B, Nakayasu M, Onjo M,
Sugimoto Y and Mizutani M. Novel steroidal
saponins from Dioscorea esculenta (Togedokoro).
Biosci. Biotechnol. Biochem. (2017) 81: 2253-60.
(16) Kim N, Kim SH, Kim YJ, Kim JK, Nam MK,
Rhim H, Yoon SK, Choi SZ, Son M and Kim SY.
Neurotrophic activity of DA-9801, a mixture extract
of Dioscorea japonica Thunb. and Dioscorea
nipponica Makino, in-vitro. J. Ethnopharmacol.
(2011) 137: 312-9.
(17) Thongdeeying P, Itharat A, Umehara K and
Ruangnoo S. A novel steroid and cytotoxic
constituents from Dioscorea membranacea
Pierre against hepatocellular carcinoma and
cholangiocarcinoma cells. J. Ethnopharmacol.
(2016) 194: 91-7.
(18) Menditto E, Cahir C, Aza-Pascual-Salcedo M,
Bruzzese D, Poblador-Plou B, Malo S, Costa E,
González-Rubio F, Gimeno-Miguel A and Orlando
V. Adherence to chronic medication in older
populations: application of a common protocol
among three European cohorts. Patient Prefer.
Adherence (2018) 12: 1975-87.
(19) Scala D, Menditto E, Armellino MF, Manguso F,
Monetti VM, Orlando V, Antonino A, Makoul G
and De Palma M. Italian translation and cultural
adaptation of the communication assessment tool
in an outpatient surgical clinic. BMC Health Serv.
Res. (2016) 16: 163.
(20) Woo KW, Moon E, Kwon OW, Lee SO, Kim
SY, Choi SZ, Son MW and Lee KR. Antineuroinflammatory diarylheptanoids from the
rhizomes of Dioscorea nipponica. Bioorg. Med.
Chem. Lett. (2013) 23: 3806-9.
(21) Ali Z, Smillie TJ and Khan IA. 7-Oxodioscin, a
new spirostan steroid glycoside from the rhizomes
of Dioscorea nipponica. Nat. Prod. Commun.
(2013) 8: 1-3.
(22) Li XZ, Zhang SN and Yang XY. Combination of
cheminformatics and bioinformatics to explore
the chemical basis of the rhizomes and aerial
parts of Dioscorea nipponica Makino. J. Pharm.
Pharmacol. (2017) 69: 1846-57.
(23) Yang MH, Yoon KD, Chin YW, Park JH and Kim J.
Phenolic compounds with radical scavenging and
cyclooxygenase-2 (COX-2) inhibitory activities
from Dioscorea opposita. Bioorg. Med. Chem.
(2009) 17: 2689-94.
(24) Yang MH, Chin YW, Yoon KD and Kim J. Phenolic
compounds with pancreatic lipase inhibitory
activity from Korean yam (Dioscorea opposita). J.
Enzyme Inhib. Med. Chem. (2014) 29: 1-6.
(25) Ma F, Zhang Y, Yao Y, Wen Y, Hu W, Zhang J, Liu
X, Bell AE and Tikkanen-Kaukanen C. Chemical
components and emulsification properties of
mucilage from Dioscorea opposita Thunb. Food
Chem. (2017) 228: 315-22.
(26) Osorio JN, Mosquera Martinez OM, Correa
Navarro YM, Watanabe K, Sakagami H and
Mimaki Y. Polyhydroxylated spirostanol saponins
from the tubers of Dioscorea p olygonoides. J. Nat.
Prod. (2005) 68: 1116-20.
(27) Tabopda TK, Mitaine-Offer AC, Tanaka C,
Miyamoto T, Mirjolet JF, Duchamp O, Ngadjui BT
and Lacaille-Dubois MA. Steroidal saponins from
Dioscorea preussii. Fitoterapia (2014) 97: 198-203.
(28) Sharlina ME, Yaacob W, Lazim AM, Fazry S,
Lim SJ, Abdullah S, Noordin A and Kumaran
M. Physicochemical properties of starch from
Dioscorea pyrifolia tubers. Food Chem. (2017)
220: 225-32.
(29) Zhang Y, Yu HY, Chao LP, Qu L, Ruan JY, Liu YX,
Dong YZ, Han LF and Wang T. Anti-inflammatory
steroids from the rhizomes of Dioscorea
septemloba Thunb. Steroids (2016) 112: 95-102.
(30) Zhang Y, Chao L, Ruan J, Zheng C, Yu H, Qu L,
Han L and Wang T. Bioactive constituents from
86
Dioscorea Plans: Nutra-pharmaceuticals
the rhizomes of Dioscorea septemloba Thunb.
Fitoterapia (2016) 115: 165-72.
(31) He T, Liu Y, Xiong RF, Li XY, Wang SF and
Cheng CR. A new phenanthropyran and a new
biphenanthrene from the rhizomes of Dioscorea
septemloba and their antioxidant activities. Nat.
Prod. Res. (2019) 19: 1-6.
(32) Oyama M, Tokiwano T, Kawaii S, Yoshida Y,
Mizuno K, Oh K and Yoshizawa Y. Protodioscin,
isolated from the rhizome of Dioscorea
tokoro collected in northern japan is the major
antiproliferative compound to HL-60 leukemic
cells. Curr. Bioact. Compd. (2017) 13: 170-4.
(33) Ali Z, Smillie TJ and Khan IA. Cholestane steroid
glycosides from the rhizomes of Dioscorea villosa
(wild yam). Carbohyd. Res. (2013) 370: 86-91.
(34) Dong SH, Nikolić D, Simmler C, Qiu F, van
Breemen RB, Soejarto DD, Pauli GF and Chen
SN. Diarylheptanoids from Dioscorea villosa (wild
yam). J. Nat. Prod. (2012) 75: 2168-77.
(35) Yoon KD, Chin YW, Yang MH, Choi J and Kim
J. Application of high‐speed countercurrent
chromatography–evaporative light scattering
detection for the separation of seven steroidal
saponins from Dioscorea villosa. Phytochem.
Analysis (2012) 23: 462-8.
(36) Dong SH, Cai G, Napolitano JG, Nikolić D, Lankin
DC, McAlpine JB, van Breemen RB, Soejarto DD,
Pauli GF and Chen SN. Lipidated steroid saponins
from Dioscorea villosa (wild yam). Fitoterapia
(2013) 91: 113-24.
(37) Zhang X, Jin M, Tadesse N, Dang J, Zhou T,
Zhang H, Wang S, Guo Z and Ito Y. Dioscorea
zingiberensis CH Wright: An overview on its
traditional use, phytochemistry, pharmacology,
clinical applications, quality control, and toxicity.
J. Ethnopharmacol. (2018) 220: 283-93.
(38) Wang GX, Jiang DX, Li J, Han J, Liu YT and Liu
XL. Anthelmintic activity of steroidal saponins
from Dioscorea zingiberensis CH Wright against
Dactylogyrus intermedius (Monogenea) in goldfish
(Carassius auratus). Parasitol. Res. (2010) 107:
1365-71.
(39) Du D, Jin T, Zhang R, Hu L, Xing Z, Shi N, Shen
Y and Gong M. Phenolic compounds isolated
from Dioscorea zingiberensis protect against
pancreatic acinar cells necrosis induced by sodium
taurocholate. Bioorg. Med. Chem. Lett. (2017) 27:
1467-70.
(40) Andrew R and Izzo AA. Principles of
pharmacological research of nutraceuticals. Br. J.
Pharmacol. (2017) 174: 1177-94.
(41) Santini A, Tenore GC and Novellino E.
Nutraceuticals: A paradigm of proactive medicine.
Eur. J. Pharm. Sci. (2017) 96: 53-61.
(42) Santini A and Novellino E. Nutraceuticals - shedding
light on the grey area between pharmaceuticals and
food. Expert Rev. Clin. Pharmacol. (2018) 11: 545-
7.
(43) Santini A, Cammarata SM, Capone G, Ianaro A,
Tenore GC, Pani L and Novellino E. Nutraceuticals:
Opening the debate for a regulatory framework.
Br. J. Clin. Pharmacol. (2018) 84: 659-72.
(44) Daliu P, Santini A and Novellino E. From
pharmaceuticals to nutraceuticals: Bridging
disease prevention and management. Expert Rev.
Clin. Pharmacol. (2019) 12: 1-7.
(45) Durazzo A, D’Addezio L, Camilli E, Piccinelli
R, Turrini A, Marletta L, Marconi S, Lucarini M,
Lisciani S and Gabrielli P. From plant compounds
to botanicals and back: A current snapshot.
Molecules (Basel, Switzerland) (2018) 23: 1844.
(46) Durazzo A and Lucarini M. Current shot and rethinking of antioxidant research strategy. Braz. J.
Anal. Chem. (2018) 5: 9-11.
(47) Fu SL, Hsu YH, Lee PY, Hou WC, Hung LC, Lin
CH, Chen CM and Huang YJ. Dioscorin isolated
from Dioscorea alata activates TLR4-signaling
pathways and induces cytokine expression in
macrophages. Biochem. Biophys. Res. Commun.
(2006) 339: 137-44.
(48) Dey P, Roy Chowdhuri S, Sarkar MP and
Chaudhuri TK. Evaluation of anti-inflammatory
activity and standardisation of hydro-methanol
extract of underground tuber of Dioscorea alata.
Pharm. Biol. (2016) 54: 1474-82.
(49) Pugazhendhi S, Sathya P, Palanisamy P and
Gopalakrishnan R. Synthesis of silver nanoparticles
through green approach using Dioscorea alata and
their characterization on antibacterial activities and
optical limiting behavior. J. Photochem. Photobiol.
B (2016) 159: 155-60.
(50) Mao X, Lu J, Huang H, Gao X, Zheng H, Chen
Y, Li X and Gao W. Four types of winged yam
(Dioscorea alata L.) resistant starches and their
effects on ethanol-induced gastric injury in-vivo.
Food Hydrocoll. (2018) 85: 21-9.
(51) Chen CT, Wang ZH, Hsu CC, Lin HH and Chen
JH. Taiwanese and Japanese yam (Dioscorea
spp.) extracts attenuate doxorubicin-induced
cardiotoxicity in mice. J. Food Drug Anal. (2017)
25: 872-80.
(52) Chen T, Hu S, Zhang H, Guan Q, Yang Y and Wang
X. Anti-inflammatory effects of Dioscorea alata L.
anthocyanins in a TNBS-induced colitis model.
Food Funct. (2017) 8: 659-69.
(53) Rakotobe L, Berkal M, Huet H, Djediat C, Jeannoda
V, Bodo B, Mambu L, Crespeau F and Edery M.
87
Salehi B et al. / IJPR (2019), 18 (Special Issue): 68-89
Effects of Madagascar yam extracts, Dioscorea
antaly, on embryo-larval development of medaka
fish, Oryzias latipes. Toxicon. (2010) 55: 87-91.
(54) Choi EM, Koo SJ and Hwang JK. Immune cell
stimulating activity of mucopolysaccharide isolated
from yam (Dioscorea batatas). J. Ethnopharmacol.
(2004) 91: 1-6.
(55) Jin M, Suh SJ, Yang JH, Lu Y, Kim SJ, Kwon
S, Jo TH, Kim JW, Park YI and Ahn GW. Antiinflammatory activity of bark of Dioscorea batatas
DECNE through the inhibition of iNOS and COX2 expressions in RAW264. 7 cells via NF-κB and
ERK1/2 inactivation. Food Chem. Toxicol. (2010)
48: 3073-9.
(56) Wen CC, Shyur LF, Jan JT, Liang PH, Kuo CJ,
Arulselvan P, Wu JB, Kuo SC and Yang NS.
Traditional Chinese medicine herbal extracts of
Cibotium barometz, Gentiana scabra, Dioscorea
batatas, Cassia tora and Taxillus chinensis inhibit
SARS-CoV replication. J. Tradit. Complement.
Med. (2011) 1: 41-50.
(57) Byeon S, Oh J, Lim J, Lee J and Kim JS. Protective
effects of Dioscorea batatas flesh and peel extracts
against ethanol-induced gastric ulcer in mice.
Nutrients (2018) 10: E1680.
(58) Su PF, Li CJ, Hsu CC, Benson S, Wang SY,
Aravindaram K, Chan SI, Wu SH, Yang FL and
Huang WC. Dioscorea phytocompounds enhance
murine splenocyte proliferation ex-vivo and
improve regeneration of bone marrow cells in-vivo.
Evid. Based Complement. Alternat. Med. (2011)
2011: 731308.
(59) Su PF, Staniforth V, Li CJ, Wang CY, Chiao
MT, Wang SY, Shyur LF and Yang NS.
Immunomodulatory effects of phytocompounds
characterized by in-vivo transgenic human GMCSF promoter activity in skin tissues. J. Biomed.
Sci. (2008) 15: 813-22.
(60) Hidayat AFA, Chan CK, Mohamad J and Kadir HA.
Dioscorea bulbifera induced apoptosis through
inhibition of ERK 1/2 and activation of JNK
signaling pathways in HCT116 human colorectal
carcinoma cells. Biomed. Pharmacother.
(2018) 104: 806-16.
(61) Ghosh S, Parihar V, More P, Dhavale D and
Chopade B. Phytochemistry and therapeutic
potential of medicinal plant: Dioscorea bulbifera.
Med. chem. (2015) 5: 154-9.
(62) Nguelefack TB, Dutra RC, Paszcuk AF, Andrade
EL, Tapondjou LA and Calixto JB. Antinociceptive
activities of the methanol extract of the bulbs
of Dioscorea bulbifera L. var sativa in mice is
dependent of NO–cGMP–ATP-sensitive-K+
channel activation. J. Ethnopharmacol. (2010)
128: 567-74.
(63) Hu K and Yao X. The cytotoxicity of
protoneodioscin (NSC-698789), a furostanol
saponin from the rhizomes of Dioscorea collettii
var. hypoglauca, against human cancer cells invitro. Phytomedicine (2002) 9: 560-5.
(64) Hu K and Yao X. The cytotoxicity of methyl
protoneogracillin (NSC‐698793) and gracillin
(NSC‐698787), two steroidal saponins from the
rhizomes of Dioscorea collettii var. hypoglauca,
against human cancer cells in-vitro. Phytother. Res.
(2003) 17: 620-6.
(65) Kunwar RM, Burlakoti C, Chowdhary CL and
Bussmann RW. Medicinal plants in farwest Nepal:
Indigenous uses and pharmacological validity.
Med. Aromat. Plant Sci. Biotechnol. (2010) 4: 28-
42.
(66) Upreti RP and Gyawali R. Antimicrobial activity
and phytochemical screening of some traditionally
used Nepalese medicinal plants. Int. J. Pharm.
Biol. Arch. (2015) 6: 20-5.
(67) Murugan M and Mohan VR. In-vitro antioxidant
studies of Dioscorea esculenta (Lour). Burkill.
Asian Pac. J. Trop. Biomed. (2012) 2: S1620-S4.
(68) Lee MY, Lee NH, Jung D, Lee JA, Seo CS, Lee
H, Kim JH and Shin HK. Protective effects of
allantoin against ovalbumin (OVA)-induced lung
inflammation in a murine model of asthma. Int.
Immunopharmacol. (2010) 10: 474-80.
(69) Kaladhar D, Rao VN, Barla S and Harasreeramulu
S. Comparative antimicrobial studies of Dioscorea
Hamiltonii hook. f. tubers with Azadirachta indica
Stem. J. Pharm. Sci. Technol. (2010) 2: 284-7.
(70) Zhao C, Li X, Miao J, Jing S, Li X, Huang L and
Gao W. The effect of different extraction techniques
on property and bioactivity of polysaccharides
from Dioscorea hemsleyi. Int. J. Biol. Macromol.
(2017) 102: 847-56.
(71) Ashri A, Amalina N, Kamil A, Fazry S, Sairi MF,
Nazar MF and Lazim AM. Modified Dioscorea
hispida starch-based hydrogels and their in-vitro
cytotoxicity study on small intestine cell line
(FHS-74 Int). Int. J. Biol. Macromol. (2018) 107:
2412-21.
(72) Theerasin S and Baker A. Analysis and
identification of phenolic compounds in Dioscorea
hispida Dennst. Asian J. Food Agro-Industry.
(2009) 2: 547-60.
(73) Chiu CS, Deng JS, Chang HY, Chen YC, Lee
MM, Hou WC, Lee CY, Huang SS and Huang
GJ. Antioxidant and anti-inflammatory properties
of Taiwanese yam (Dioscorea japonica Thunb.
var. pseudojaponica (Hayata) Yamam.) and its
reference compounds. Food Chem. (2013) 141:
88
Dioscorea Plans: Nutra-pharmaceuticals
1087-96.
(74) Tewtrakul S and Itharat A. Nitric oxide inhibitory
substances from the rhizomes of Dioscorea
membranacea. J. Ethnopharmacol. (2007) 109:
412-6.
(75) Panthong S, Ruangnoo S, Thongdeeying P,
Sriwanthana B and Itharat A. Immunomodulatory
activity of Dioscorea membranacea Pierre
rhizomes and of its main active constituent
Dioscorealide B. BMC Complement. Altern. Med.
(2014) 14: 403.
(76) Woo KW, Kwon OW, Kim SY, Choi SZ, Son MW,
Kim KH and Lee KR. Phenolic derivatives from
the rhizomes of Dioscorea nipponica and their antineuroinflammatory and neuroprotective activities.
J. Ethnopharmacol. (2014) 155: 1164-70.
(77) Tewtrakul S and Itharat A. Anti-allergic substances
from the rhizomes of Dioscorea membranacea.
Bioorg. Med. Chem. (2006) 14: 8707-11.
(78) Zhou Q, Yu DH, Liu SM and Liu Y. Total saponins
from Discorea nipponica makino ameliorate urate
excretion in hyperuricemic rats. Pharmacogn.
Mag. (2015) 11: 567-73.
(79) Zhou Q, Yu DH, Zhang C, Liu SM and Lu F. Total
saponins from Discorea nipponica ameliorate urate
excretion in hyperuricemic mice. Planta Med.
(2014) 80: 1259-68.
(80) Wang T, Choi RC, Li J, Bi CW, Ran W, Chen
X, Dong TT, Bi K and Tsim KW. Trillin, a
steroidal saponin isolated from the rhizomes of
Dioscorea nipponica, exerts protective effects
against hyperlipidemia and oxidative stress. J.
Ethnopharmacol. (2012) 139: 214-20.
(81) Tang Y. Comparative study on the morphology,
chemistry, metabolism and anti-myocardial
ischemia activity of three medicinal species of
Dioscorea [dissertation]. HKBU Institutional
Repository, Hong Kong (2015) 1-176.
(82) Yang MH, Yoon KD, Chin YW, Park JH, Kim
SH, Kim YC and Kim J. Neuroprotective effects
of Dioscorea opposita on scopolamine-induced
memory impairment in in-vivo behavioral tests and
in vitro assays. J. Ethnopharmacol. (2009) 121:
130-4.
(83) Liu Y, Li H, Fan Y, Man S, Liu Z, Gao W and
Wang T. Antioxidant and antitumor activities
of the extracts from Chinese yam (Dioscorea
opposite Thunb.) flesh and peel and the effective
compounds. J. Food Sci. (2016) 81: H1553-64.
(84) Ghosh S, Gurav S, Harke A, Chacko M, Joshi
K, Dhepe A, Charolkar C, Shinde V, Kitture R
and Parihar V. Dioscorea oppositifolia mediated
synthesis of gold and silver nanoparticles with
catalytic activity. J. Nanomed. Nanotechnol.
(2016) 7: 1-7.
(85) Li Q, Li W, Gao Q and Zou Y. Hypoglycemic effect
of Chinese yam (Dioscorea opposita rhizoma)
polysaccharide in different structure and molecular
weight. J. Food Sci. (2017) 82: 2487-94.
(86) Kumar S, Mahanti P, Singh NR, Rath SK, Jena PK
and Patra JK. Antioxidant activity, antibacterial
potential and characterization of active fraction of
Dioscorea pentaphylla L. tuber extract collected
from Similipal Biosphere Reserve, Odisha, India.
Braz. J. Pharm. Sci. (2017) 53: 1-10.
(87) Tang YN, He XC, Ye M, Huang H, Chen HL, Peng
WL, Zhao ZZ, Yi T and Chen HB. Cardioprotective
effect of total saponins from three medicinal
species of Dioscorea against isoprenaline-induced
myocardial ischemia. J. Ethnopharmacol. (2015)
175: 451-5.
(88) Yang L, Liu X, Zhuang X, Feng X, Zhong L and
Ma T. Antifungal effects of Saponin extract from
Rhizomes of Dioscorea panthaica Prain et Burk
against Candida albicans.Evid. Based Complement.
Alternat. Med. (2018) 2018: 6095307.
(89) McKoy ML, Thomas PG, Asemota H, Omoruyi
F and Simon O. Effects of Jamaican bitter yam
(Dioscorea polygonoides) and diosgenin on blood
and fecal cholesterol in rats. J. Med. Food (2014)
17: 1183-8.
(90) McAnuff M, Omoruyi F, Morrison ESA and
Asemota H. Changes in some liver enzymes in
streptozotocin-induced diabetic rats fed sapogenin
extract from bitter yam (Dioscorea polygonoides)
or commercial diosgenin. West Indian Med. J.
(2005) 54: 97-101.
(91) Chen Y, Chen XL, Xiang T, Sun BG, Luo HX,
Liu MT, Chen ZX, Zhang SJ and Wang CJ. Total
saponins from Dioscorea septemloba thunb reduce
serum uric acid levels in rats with hyperuricemia
through OATP1A1 up-regulation. J. Huazhong
Univ. Sci. Technol. Med. Sci. (2016) 36: 237-42.
(92) Fei Y, Ye D, Fan X and Dong F. Effect of Dioscorea
tokoro Makino extract on hyperuricemia in mice.
Trop. J. Pharm. Res. (2016) 15: 1883-7.
(93) Teixeira A, Oliveira I, Lima E and Matsuura T. The
use of purple yam (Dioscorea trifida) as a healthpromoting ingredient in bread making. J. Res. Biol.
(2013) 3: 747-58.
(94) Mollica JQ, Cara DC, D’Auriol M, Oliveira VB,
Cesar IC and Brandão MG. Anti-inflammatory
activity of American yam Dioscorea trifida Lf
in food allergy induced by ovalbumin in mice. J.
Funct. Foods (2013) 5: 1975-84.
(95) Roy A, Geetha R and Lakshmi T. Valuation of
the antibacterial activity of ethanolic extract of
Dioscorea villosa tubers-an in-vitro study. Int. J.
89
Salehi B et al. / IJPR (2019), 18 (Special Issue): 68-89
Pharm. Pharm. Sci. (2012) 4: 314-6.
(96) Siddiqui MA, Ali Z, Chittiboyina AG and Khan
IA. Hepatoprotective effect of steroidal glycosides
from Dioscorea villosa on hydrogen peroxideinduced hepatotoxicity in HepG2 cells. Front.
Pharmacol. (2018) 9: 797.
(97) Lima CM, Lima AK, Melo MGD, Serafini MR,
Oliveira DL, de Almeida EB, Barreto RSS, de
Lima Nogueira PC, de Souza Moraes VR and
Oliveira ÉRA. Bioassay-guided evaluation of
Dioscorea villosa–an acute and subchronic toxicity,
antinociceptive and anti-inflammatory approach.
BMC Complement. Altern. Med. (2013) 13: 195.
(98) Zhang XX, Ito Y, Liang JR, Liu JL, He J and Sun WJ.
Therapeutic effects of total steroid saponin extracts
from the rhizome of Dioscorea zingiberensis CH
Wright in Freund’s complete adjuvant induced
arthritis in rats. Int. Immunopharmacol. (2014) 23:
407-16.
(99) Cho J, Choi H, Lee J, Kim MS, Sohn HY and
Lee DG. The antifungal activity and membranedisruptive action of dioscin extracted from
Dioscorea nipponica. Biochim. Biophys. Acta
(2013) 1828: 1153-8.
(100) Huang H, Jiang Q, Chen Y, Li X, Mao X, Chen
X, Huang L and Gao W. Preparation, physico–
chemical characterization and biological activities
of two modified starches from yam (Dioscorea
Opposita Thunb.). Food Hydrocoll. (2016) 55:
244-53.
(101) Mei X, Xu D, Xu S, Zheng Y and Xu S. Novel
role of Zn (II)–curcumin in enhancing cell
proliferation and adjusting proinflammatory
cytokine-mediated oxidative damage of ethanolinduced acute gastric ulcers. Chem. Biol. Interact.
(2012) 197: 31-9.
(102) Li H, Huang W, Wen Y, Gong G, Zhao Q and
Yu G. Anti-thrombotic activity and chemical
characterization of steroidal saponins from
Dioscorea zingiberensis CH Wright. Fitoterapia
(2010) 81: 1147-56.
(103) Huang CH, Ku CY and Jan TR. Diosgenin
attenuates allergen-induced intestinal inflammation
and IgE production in a murine model of food
allergy. Planta Med. (2009) 75: 1300-5.
(104) Saldanha J, Gargiulo D, Silva S, Carmo-Pinto F,
Andrade M, Alvarez-Leite J, Teixeira M and Cara
D. A model of chronic IgE-mediated food allergy
in ovalbumin-sensitized mice. Braz. J. Med. Biol.
Res. (2004) 37: 809-16.
(105) Olayemi J and Ajaiyeoba E. Anti-inflammatory
studies of yam (Dioscorea esculenta) extract on
wistar rats. Afr. J. Biotechnol. (2007) 6: 1913-5.
(106) Gyawali R, Dhakal A, Bohara DB and Adhikari N.
Anti-inflammatory and antimicrobial property of
Dioscorea deltoidea L from Nepal. (2010) 5: 72-5.
(107) Jeon S, Lee CH, Liu QF, Kim GW, Koo BS and
Pak SC. Alteration in brain-derived neurotrophic
factor (BDNF) after treatment of mice with herbal
mixture containing Euphoria longana, Houttuynia
cordata and Dioscorea japonica. DARU (2014)
22: 77.
(108) Li T, Teng H, An F, Huang Q, Chen L and Song H.
The beneficial effects of purple yam (Dioscorea
alata L.) resistant starch on hyperlipidemia in
high-fat-fed hamsters. Food Funct. (2019) 10:
2642-50.
(109) Teng H, An F, Huang Q, Chen L and Song H. The
beneficial effects of purple yam (Dioscorea alata
L.) resistant starch on hyperlipidemia in high-fatfed hamsters. (2019) 10: 2642-50.
(110) Komesaroff PA, Black CVS, Cable V and Sudhir
K. Effects of wild yam extract on menopausal
symptoms, lipids and sex hormones in healthy
menopausal women. Climacteric (2001) 4: 144-50
)