Chemical Composition, Antioxidant, Genotoxique and Antigenotoxic Potentials of Phlomis Bovei De Noé Aerial Parts

Document Type: Research article

Authors

1 UMR 5557 CNRS-UCBL – Ecologie Microbienne, Université Lyon 1, Villeurbanne, France.

2 Département de Chimie, Laboratoire de Recherche en Phytochimie et Analyse Physicochimique, Université Mentouri, Constantine, Algeria.

3 Laboratoire de Biologie Moléculaire et Cellulaire, Faculté de Médecine Dentaire de Monastir, Tunisia.

Abstract

In the present work, chemical investigation of the aerial parts of Phlomis bovei de Noé an endemic species from Algeria, led to the isolation and identification of seven known compounds including five flavones glycosides: Chrysoeriol 7-O-(3’’-(E et Z)-p-coumaroyl)-β-glucoside (1), terniflorin (apigenin-7-O-(6’’-E-p-coumaroyl)glucoside) (3), apigenin-7-O-(6’’-(5’’’-methoxy-coumaryl) glucoside (4), apigenin 7-O-(3″-p-coumaryl)glucoside(5), hispidulin-7-O-glucuronide (6) and two cinnamic acid derivatives: p-coumaric acid methyl ester (E et Z) (2), chlorogenic acid (7). Compound 4 is described for the first time in the species bovei de Noé , the genus Phlomis and the Lamiaceae family. Structures elucidation was performed by comprehensive 1D and 2D NMR analyses, mass spectrometry and by comparison with literature data. Some pure compounds and extracts have been evaluated for their antioxidant activities through different methods: DPPH and ABTS assays as well as CUPRAC assay. Genotoxic and antigenotoxic activities of pure compounds were also evaluated in-vitro on Escherichia coli PQ37 cells by the SOS Chromotest.

Graphical Abstract

Chemical Composition, Antioxidant, Genotoxique and Antigenotoxic Potentials of Phlomis Bovei De Noé Aerial Parts

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