References
Global tuberculosis report 2018. Available from: URL:
https://www.who.int/tb/publicat ions /global_report/
en.
Tunerculosis: Key Facts. Available from: URL: http://
www.who.int /mediacentre/factsheets/fs104/en/index.
html.
Tuberculosis-WHO India. Available from: URL:
http://whoindia.org/EN /Section3/Section123.html.
Udwadia ZF, Amale RA, Ajbani KK and Rodrigues
C. Totally drug-resistant tuberculosis in India. Clin.
Infect. Dis. (2012) 54: 579-81.
Asselineau J and Lederer E. Structure of the Mycolic
Acids of Mycobacteria. Nature (1950) 166: 782-3.
Rozwarski DA Grant GA, Barton DH, Jacobas WR
JR and Sacchettini JC. Modification of the NADH
of the isoniazid target (InhA) from Mycobacterium
tuberculosis. Science (1998) 2.79: 98-102.
Lei B, Wei CJ and Tu SC. Action Mechanism of
Antitubercular Isoniazid Activation by mycobacterium
tuberculosis katG, isolation, and characterization of
inhA inhibitor. J. Biol. Chem. (2000) 275: 2520-6.
Rawat R, Whitty A and Peter JT. The isoniazid-NAD
adduct is a slow, tight-binding inhibitor of InhA, the
Mycobacterium tuberculosis enoyl reductase: Adduct
affinity and drug resistance. Proc. Natl. Acad. Sci. U.
S. A. (2003) 100: 13881-6.
Parikh SL, Xiao G and Tonge PJ. Inhibition of
InhA, the Enoyl Reductase from Mycobacterium
tuberculosis, by Triclosan and Isoniazid. Biochemistry
(2000) 39: 7645-50.
Pan P and Tonge PJ. Targeting InhA, the FASII
enoyl-ACP reductase: SAR studies on novel inhibitor
scaffolds. Curr. Topics Med. Chem. (2012) 12: 672-
693.
Luckner SR, Liu N, Am-Ende CW, Tonge PJ and
Kisker C. A slow, tight-binding inhibitor of InhA,
the enoyl-ACP reductase from Mycobacterium
tuberculosis. J. Biol. Chem. (2010) 285: 14330-7.
Am Ende CW, Knudson SE, Liu N, Childs J, Sullivan
TJ, Boyne M, Xu H, Gegina Y, Knudson DL, Johnson
F, Peloquin CA, Slayden RA and Tonge PJ. Synthesis
and in-vitro antimycobacterial activity of B-ring
modified diaryl ether InhA inhibitors. Bioorg. Med.
Chem. Lett. (2008) 18: 3029-33.
Amir M, Kumar H and Javed SA. Condensed
bridgehead nitrogen heterocyclic system: Synthesis
and pharmacological activities of 1,2,4-triazolo-[3,4-
b]-1,3,4-thiadiazole derivatives of ibuprofen and
(1)
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
(10)
(11)
(12)
(13)
biphenyl-4-yloxy acetic acid. J. Med. Chem. (2008)
43: 2056-66.
Amir M and Shikha K. Synthesis and anti-inflammatory,
analgesic, ulcerogenic and lipid peroxidation activities
of some new 2-[(2,6-dichloroanilino) phenyl]acetic
acid derivatives. Eur. J. Med. Chem. (2004) 39: 535-
45.
Reid JR and Heindel ND. Improved syntheses of 5‐
substituted‐4‐amino‐3‐mercapto‐(4H)1,2,4-triazoles.
J. Heterocycl. Chem. (1976) 13: 925-6.
Patil V, Tilekar K, Sonali MM, Mohan R and Ramaa
CS. Synthesis and primary cytotoxicity evaluation of
new 5-benzylidene-2,4-thiazolidinedione derivatives.
Eur. J. Med. Chem. (2010) 45: 4539-44.
Bhanushali U, Saranya R, Keerthana S, Pushkar K,
Kiran C, Chatterjee S and Ramaa CS. 5-benzylidene2,4-thiazolidenedione derivatives: Design, synthesis
and evaluation as inhibitors of angiogenesis targeting
VEGR-2. Bioorg. Chem. (2016) 67: 139-47.
Joshi H, Marulkar K, Gota V and Ramaa CS. Hydroxy
cinnamic acid derivatives as partial PPARγ agonists: In
silico studies, synthesis and biological characterization
against chronic myeloid leukemia cell line (K-562).
Anti-Cancer Agents Med. Chem. (2017) 17: 524-41.
Kabir A, Tilekar K, Upadhyay N and Ramaa CS.
Novel anthraquinone derivatives as dual inhibitors
of topoisomerase 2 and casein kinase 2: In silico
studies, synthesis and biological evaluation on human
leukemic cell lines. Anti-Cancer Agents Med. Chem.
(2018) 18: 1551-62.
Joshi SD, Vagdevi HM, Vaidya VP and Gadaginamath
GS. Synthesis of new 4-pyrrol-1-yl benzoic acid
hydrazide analogs and some derived oxadiazole,
triazole and pyrrole ring systems: A novel class of
potential antibacterial and antitubercular agents. Eur.
J. Med. Chem. (2008) 43: 1989-96.
Zhou CH and Wang Y. Recent researches in triazole
compounds as medicinal drugs. Curr. Med. Chem.
(2012) 19: 239-80.
Daina, A. SwissADME: a free web tool to evaluate
pharmacokinetics, druglikeness and medicinal
chemistry friendliness of small molecules. Sci. Reports
(2016) 7: 42717.
Daina, A and Zoete, V. A BOILED-Egg to Predict
Gastrointestinal Absorption and Brain Penetration of
Small Molecules. ChemMedChem (2016) 11: 1117–21.
Aydogan F, Turgut Z and Ocal N. Synthesis and
electronic structure of new aryl-and alkyl-substituted
1,3,4-oxadiazole-2-thione derivatives. Turk. J. Chem.
(2002) 26: 159-69.