Comparative Study of the Effects of Chamomile (Matricaria Chamomilla L.) and Cabergoline on Idiopathic Hyperprolactinemia: A Pilot Randomized Controlled Trial

Document Type: Research article

Authors

1 School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.

2 School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Institute of Family Health, Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran.

4 Vali-e-Asr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Chamomile is a fascinating plant quoted in several traditional medicine texts, which has
broad-spectrum pharmacological activity and medicinal uses. The aim of this study was to
assess the efficacy of chamomile syrup in reducing serum prolactin in women with idiopathic
hyperprolactinemia. The study was a randomized, controlled clinical trial that was conducted
on 56 women with idiopathic hyperprolactinemia for a study period of four weeks. Patients
were randomly enrolled in two parallel arms and were treated by chamomile syrup at a dose
of 5 mL twice daily or cabergoline tablet orally at a dose of 0.25 mg twice weekly. Serum
prolactin levels were measured at baseline and the end of the 4-week study period. Any report
of adverse events was also recorded. Results revealed that within the cabergoline group the
reduction in the mean prolactin level was significantly greater than that of the chamomile
group (
p <0.0001). It was also found that decline in the mean prolactin level was statistically
significant within the chamomile group (
p <0.0001). Chamomile syrup seems to be effective
on serum prolactin reduction in women with idiopathic hyperprolactinemia. However, studies
with a larger sample size and for a longer follow-up period are recommended.

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