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Saadat, S., Yasavoli, M., Gholamnezhad, Z., Aslani, M., Boskabady, M. (2019). The Relaxant Effect of Crocin on Rat Tracheal Smooth Muscle and Its Possible Mechanisms. Iranian Journal of Pharmaceutical Research, 18(3), 1358-1370. doi: 10.22037/ijpr.2019.1100713
Saeideh Saadat; Mahsa Yasavoli; Zahra Gholamnezhad; Mohammad Reza Aslani; Mohammad Hossein Boskabady. "The Relaxant Effect of Crocin on Rat Tracheal Smooth Muscle and Its Possible Mechanisms". Iranian Journal of Pharmaceutical Research, 18, 3, 2019, 1358-1370. doi: 10.22037/ijpr.2019.1100713
Saadat, S., Yasavoli, M., Gholamnezhad, Z., Aslani, M., Boskabady, M. (2019). 'The Relaxant Effect of Crocin on Rat Tracheal Smooth Muscle and Its Possible Mechanisms', Iranian Journal of Pharmaceutical Research, 18(3), pp. 1358-1370. doi: 10.22037/ijpr.2019.1100713
Saadat, S., Yasavoli, M., Gholamnezhad, Z., Aslani, M., Boskabady, M. The Relaxant Effect of Crocin on Rat Tracheal Smooth Muscle and Its Possible Mechanisms. Iranian Journal of Pharmaceutical Research, 2019; 18(3): 1358-1370. doi: 10.22037/ijpr.2019.1100713

The Relaxant Effect of Crocin on Rat Tracheal Smooth Muscle and Its Possible Mechanisms

Article 20, Volume 18, Issue 3, Summer 2019, Page 1358-1370  XML PDF (575.59 K)
Document Type: Research article
DOI: 10.22037/ijpr.2019.1100713
Authors
Saeideh Saadat1, 2; Mahsa Yasavoli1, 2; Zahra Gholamnezhadorcid 1, 2; Mohammad Reza Aslani3; Mohammad Hossein Boskabady email 1, 2
1Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
2Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3Ardabil Imam Khomeini Educational and Clinical Hospital, Ardabil University of Medical Sciences, Ardabil, Iran.
Abstract
Crocin, a component of saffron, showed hypotensive which is perhaps due to vascular smooth muscle relaxant effect. The relaxant effects of saffron on tracheal smooth muscle also could be due to its constituent, crocin. In the present study, the relaxant effects of crocin and its possible mechanisms on rat tracheal smooth muscle were investigated. The relaxant effects of three cumulative concentrations of crocin (30, 60, and 120 μM) or theophylline (0.2, 0.4, 0.6 mM) as positive control was examined on pre-contracted tracheal smooth muscle by methacholine or KCl in non-incubated or incubated conditions with different agents including atropine, chlorpheniramine, indomethacin, diltiazem, glibenclamide and propranolol. In non-incubated tracheal smooth muscle, crocin showed significant relaxant effects on KCl induced muscle contraction (p
Keywords
Crocin; Smooth muscle; Trachea; Receptors; Adrenergic; Muscarinic
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